CLIP170 Antibody (OAPB00704)

Catalog No: OAPB00704

Size:100UG

Western blot analysis of CLIP170 in rat brain tissue lysate with CLIP170 antibody at (A) 0.5 and (B) 1 ug/mL.

Immunofuorescence of CLIP170 in human brain tissue with CLIP170 antibody at 20 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. CLIP170 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: CLIP170 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: CLIP170 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170. The immunogen is located within amino acids 1340 - 1390 of CLIP170.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-CLIP170 antibody is Catalog # OEPB02814
• Application Info: CLIP170 antibody can be used for detection of CLIP170 by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)
• Other Applications Image 1 Data: Immunofuorescence of CLIP170 in human brain tissue with CLIP170 antibody at 20 ug/mL.
• Reference: Bilbe G, Delabie J, Bruggen J, et al. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin’s disease. EMBO J.1992; 11:2103-13.;Diamantopoulos GS, Perez F, Goodson HV, et al. Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly. J. Cell Biol.1999; 144:99-112.;Pierre P, Scheel J, Richard JE, et al. CLIP-170 links endocytic vesicles to microtubules. Cell70:887-900.;Suzuki K and Takahashi K. Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells. Biochem. Biophys. Res. Commun.2008; 368:199-204.

Target Info

• Gene Symbol: CLIP1
• Gene Full Name: CAP-Gly domain containing linker protein 1
• Alias Symbols: CAP-Gly domain-containing linker protein 1;CLIP;CLIP170;CLIP-170;CYLN1;cytoplasmic linker protein 1;cytoplasmic linker protein 170 alpha-2;cytoplasmic linker protein CLIP-170;Reed-Sternberg intermediate filament-associated protein;Restin;restin (Reed-Steinberg cell-expressed intermediate filament-associated protein);RSN.
• NCBI Gene Id: 6249
• Protein Name: CAP-Gly domain-containing linker protein 1|CAP-Gly domain-containing linker protein 1 isoform a [Homo sapiens]
• Description of Target: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
• Uniprot ID: P30622
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_002947