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CLDN5 antibody - C-terminal region (ARP33627_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP33627_P050-FITC Conjugated

ARP33627_P050-HRP Conjugated

ARP33627_P050-Biotin Conjugated

Gene Symbol:
CLDN5
NCBI Gene Id:
7122
Official Gene Full Name:
Claudin 5
Protein Name:
Claudin-5
Swissprot Id:
O00501
Protein Accession #:
NP_003268
Nucleotide Accession #:
NM_003277
Alias Symbols:
AWAL, BEC1, CPETRL1, TMVCF
Replacement Item:
This antibody may replace item sc-114920 from Santa Cruz Biotechnology.
Description of Target:
CLDN5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
218
Molecular Weight:
23kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CLDN5.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CLDN5.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN5
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Guinea Pig: 86%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 93%
Complete computational species homology data:
Anti-CLDN5 (ARP33627_P050)
Peptide Sequence:
Synthetic peptide located within the following region: GWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKKN
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; MPDZ; CLDN3; CLDN5; TJP1; CLDN1;
Blocking Peptide:
For anti-CLDN5 (ARP33627_P050) antibody is Catalog # AAP33627 (Previous Catalog # AAPP04683)
Datasheets/Manuals:
Printable datasheet for anti-CLDN5 (ARP33627_P050) antibody
Target Reference:
Fontijn,R.D., Am. J. Physiol. Heart Circ. Physiol. 294 (2), H891-H900 (2008)
Publications:

Yang, R; Liu, W; Miao, L; Yang, X; Fu, J; Dou, B; Cai, A; Zong, X; Tan, C; Chen, H; Wang, X; Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier. 7, 63839-63855 (2016). WB, Cow, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat 27588479

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