CILP Recombinant Protein (OPCD02223)

Catalog No: OPCD02223

CILP Recombinant Protein (OPCD02223) using SDS-PAGE

CILP Recombinant Protein (OPCD02223) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile603-Ala846
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: CILP
• Gene Full Name: cartilage intermediate layer protein
• Alias Symbols: cartilage intermediate layer protein 1;cartilage intermediate layer protein 1 C1;cartilage intermediate layer protein 1 C2;cartilage intermediate layer protein, nucleotide pyrophosphohydrolase;Cartilage intermediate-layer protein;CILP-1;HsT18872.
• NCBI Gene Id: 8483
• Protein Name: Cartilage intermediate layer protein 1
• Description of Target: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
• Uniprot ID: O75339
• Protein Accession #: NP_003604.3
• Nucleotide Accession #: NM_003613.3
• Protein Size (# AA): Ile603~Ala846
• Molecular Weight: 58kDa