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CIITA Antibody (OADC00027)

  • Catalog#: OADC00027
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Predicted Species Reactivity:
Human
Product Format:
Liquid. Provided in PBS containing 0.05% azide and 0.05% ProClin 300.
Clonality:
Polyclonal
Host:
Rabbit
Conjugation:
Unconjugated
Application:
CHIP
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item:
This antibody may replace item sc-13556 from Santa Cruz Biotechnology.
Purification:
Affinity purified
Concentration:
1 mg/mL
Datasheets/Manuals:
Printable datasheet for anti-CIITA (OADC00027) antibody
Preservative:
0.05% Sodium Azide and 0.05% ProClin 300.
Specificity:
Polyclonal antibody raised in rabbit against human CIITA protein (MHC class II transactivator), using a recombinant protein.
Application Info:
CHIP: 5-7 ug/IP
Gene Symbol:
CIITA
Official Gene Full Name:
class II, major histocompatibility complex, transactivator
Alias Symbols:
C2TA, NLRA, MHC2TA, CIITAIV
NCBI Gene Id:
4261;
Protein Name:
MHC class II transactivator
Description of Target:
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Swissprot Id:
P33076
Protein Accession #:
NP_000237.2
Nucleotide Accession #:
NM_000246.3
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CIITA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CIITA.

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