Size:50 ug
$298.00
Discontinued
SKU
OADC00027
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CIITA Antibody (OADC00027)

Catalog#: OADC00027
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More Information
Predicted Species Reactivity Human
Product Format Liquid. Provided in PBS containing 0.05% azide and 0.05% ProClin 300.
Clonality Polyclonal
Host Rabbit
Conjugation Unconjugated
Application CHIP
Reconstitution and Storage Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item This antibody may replace item sc-13556 from Santa Cruz Biotechnology.
Purification Affinity purified
Concentration 1 mg/mL
Datasheets/Manuals Printable datasheet for anti-CIITA (OADC00027) antibody
Preservative 0.05% Sodium Azide and 0.05% ProClin 300.
Specificity Polyclonal antibody raised in rabbit against human CIITA protein (MHC class II transactivator), using a recombinant protein.
Application Info CHIP: 5-7 ug/IP
Gene Symbol CIITA
Official Gene Full Name class II, major histocompatibility complex, transactivator
Alias Symbols C2TA, NLRA, MHC2TA, CIITAIV
NCBI Gene Id 4261;
Protein Name MHC class II transactivator
Description of Target This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Swissprot Id P33076
Protein Accession # NP_000237.2
Nucleotide Accession # NM_000246.3
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express CIITA.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express CIITA.
  1. What is the species homology for "CIITA Antibody (OADC00027)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "CIITA Antibody (OADC00027)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "CIITA Antibody (OADC00027)" provided in?

    This item is provided in "Liquid. Provided in PBS containing 0.05% azide and 0.05% ProClin 300.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CIITA Antibody (OADC00027)"?

    This target may also be called "C2TA, NLRA, MHC2TA, CIITAIV" in publications.

  5. What is the shipping cost for "CIITA Antibody (OADC00027)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CIITA Antibody (OADC00027)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CIITA Antibody (OADC00027)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CIITA Antibody (OADC00027)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "CIITA"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CIITA"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CIITA"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CIITA"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CIITA"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CIITA"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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