CHP1 Recombinant Protein (OPCD00844)

Catalog No: OPCD00844

CHP1 Recombinant Protein (OPCD00844) using SDS-PAGE

CHP1 Recombinant Protein (OPCD00844) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly2-His195
  Subcellular Location: Membrane, Nucleus, Cytoplasm
  Isoelectric Point: 5.0
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 1000 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CHP1
• Gene Full Name: calcineurin like EF-hand protein 1
• Alias Symbols: calcineurin B homolog;calcineurin B homologous protein 1;calcineurin B-like protein;calcineurin homologous protein;calcium binding protein P22;calcium-binding protein CHP;calcium-binding protein p22;CHP;EF-hand calcium-binding domain-containing protein p22;p22;p24;Sid470p;SLC9A1 binding protein;SLC9A1BP;SPAX9.
• NCBI Gene Id: 11261
• Protein Name: Calcineurin B homologous protein 1
• Description of Target: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
• Uniprot ID: Q99653
• Protein Accession #: NP_009167.1
• Nucleotide Accession #: NM_007236.4
• Protein Size (# AA): Gly2~His195
• Molecular Weight: 27kDa