Catalog No: OPCA04962
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OPCA04962
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CHMP4B Recombinant Protein (Human) (OPCA04962)

Datasheets/ManualsPrintable datasheet for CHMP4B Recombinant Protein (Human) (OPCA04962) (OPCA04962)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLiquid or Lyophilized powder
Additional InformationSpecies Specificity Detail: Homo sapiens (Human)
Reconstitution and Storage-20°C or -80°C
FormulationTris-base, 50% glycerol
PurityGreater than 90% as determined by SDS-PAGE.
Peptide SequenceSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGEEFDEDELMAELEELEQEELDKNLLEISGPETVPLPNVPSIALPSKPAKKKEEEDDDMKELENWAGSM
Protein SequenceSVFGKLFGAGGGKAGKGGPTPQEAIQRLRDTEEMLSKKQEFLEKKIEQELTAAKKHGTKNKRAALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTNTEVLKNMGYAAKAMKAAHDNMDIDKVDELMQDIADQQELAEEISTAISKPVGFGEEFDEDELMAELEELEQEELDKNLLEISGPETVPLPNVPSIALPSKPAKKKEEEDDDMKELENWAGSM
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
SourceE.coli
Protein Range1-224 aa
TagN-terminal GST-tagged
ReferenceThe ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. Katoh K., Shibata H., Suzuki H., Narai A., Ishidoh K., Kominami E., Yoshimori T., Maki M. J. Biol. Chem. 278:39104-39113(2003)
Gene SymbolCHMP4B
Gene Full Namecharged multivesicular body protein 4B
Alias SymbolsC20orf178;charged multivesicular body protein 4b;CHMP4A;chromatin modifying protein 4B;chromatin-modifying protein 4b;CTPP3;CTRCT31;dJ553F4.4;hSnf7-2;hVps32-2;Shax1;SNF7;SNF7 homolog associated with Alix 1;Snf7 homologue associated with Alix 1;SNF7-2;Vacuolar protein sorting-associated protein 32-2;vacuolar protein-sorting-associated protein 32-2;Vps32-2;VPS32B.
NCBI Gene Id128866
Protein NameCharged multivesicular body protein 4b
Description of TargetProbable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Uniprot IDQ9H444
Protein Accession #NP_789782
Nucleotide Accession #NM_176812
Protein Size (# AA)Recombinant
Molecular Weight51.8 kDa
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