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| Datasheets/Manuals | Printable datasheet for CHMP4B Antibody (OACA08436) (OACA08436) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Charged multivesicular body protein 4b protein (1-224AA) |
| Purification | Affinity Purified |
| Preservative | 0.02% sodium azide |
| Formulation | PBS with, 50% glycerol, pH7.3. |
| Gene Symbol | CHMP4B |
|---|---|
| Gene Full Name | charged multivesicular body protein 4B |
| Alias Symbols | C20orf178;charged multivesicular body protein 4b;CHMP4A;chromatin modifying protein 4B;chromatin-modifying protein 4b;CTPP3;CTRCT31;dJ553F4.4;hSnf7-2;hVps32-2;Shax1;SNF7;SNF7 homolog associated with Alix 1;Snf7 homologue associated with Alix 1;SNF7-2;Vacuolar protein sorting-associated protein 32-2;vacuolar protein-sorting-associated protein 32-2;Vps32-2;VPS32B. |
| NCBI Gene Id | 128866 |
| Protein Name | Charged multivesicular body protein 4b |
| Description of Target | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
| Uniprot ID | Q9H444 |
| Protein Accession # | NP_789782 |
| Nucleotide Accession # | NM_176812 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "CHMP4B Antibody (OACA08436)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "CHMP4B Antibody (OACA08436)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "CHMP4B Antibody (OACA08436)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "CHMP4B Antibody (OACA08436)"?
This target may also be called "C20orf178;charged multivesicular body protein 4b;CHMP4A;chromatin modifying protein 4B;chromatin-modifying protein 4b;CTPP3;CTRCT31;dJ553F4.4;hSnf7-2;hVps32-2;Shax1;SNF7;SNF7 homolog associated with Alix 1;Snf7 homologue associated with Alix 1;SNF7-2;Vacuolar protein sorting-associated protein 32-2;vacuolar protein-sorting-associated protein 32-2;Vps32-2;VPS32B." in publications.
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What is the shipping cost for "CHMP4B Antibody (OACA08436)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "CHMP4B Antibody (OACA08436)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "CHMP4B Antibody (OACA08436)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "CHMP4B Antibody (OACA08436)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "CHMP4B"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "CHMP4B"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "CHMP4B"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "CHMP4B"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "CHMP4B"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "CHMP4B"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
