CHGA Antibody - middle region (OASG01566)

Catalog No: OASG01566

Size:100 uL

Western Blot using A549

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
  Tissue Specificity: GE-25 is found in the brain.
  Sequence & Domain Family: Belongs to the chromogranin/secretogranin protein family.
  Cellular Localization: Cytoplasmic vesicle > secretory vesicle lumen, Cytoplasmic vesicle > secretory vesicle membrane, Secreted, Cytoplasmic vesicle > secretory vesicle.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human Chr-A.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Sulfated on tyrosine residues and/or contains sulfated glycans. O-glycosylated with core 1 or possibly core 8 glycans. Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity. Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides.
• Specificity: Chr-A Polyclonal Antibody detects endogenous levels of Chr-A protein.
• Application Info: WB: 1:500~2000
  IHC: 1:100~300
  ELISA: 1:10000

Target Info

• Gene Symbol: CHGA
• Gene Full Name: chromogranin A
• Alias Symbols: CGA
• NCBI Gene Id: 1113; 12652;
• Description of Target: Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist . Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chemokines . Acts as a potent scavenger of free radicals in vitro . May play a role in the regulation of cardiac function and blood pressure. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
• Uniprot ID: P10645, P26339, P10354
• Molecular Weight: 68 kDa