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Catalog No: OASG01554
Size:100 uL
Price: $239.00
SKU
OASG01554
Availability: Domestic: within 2-3 weeks delivery | International: 2-3 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for anti-CHEK2 (OASG01554) antibody
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatLiquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ApplicationWB, IHC
Reconstitution and StorageStore at -20C. Avoid repeated freeze/thaw cycles.
ImmunogenSynthesized peptide derived from human Chk2 around the non-phosphorylation site of T387. Location: 330-410aa.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration1 mg/ml
SpecificityChk2 Polyclonal Antibody detects endogenous levels of Chk2 protein.
Application InfoWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Gene SymbolCHEK2
Gene Full Namecheckpoint kinase 2
Alias SymbolsCDS1, CHK2, LFS2, RAD53, hCds1, HuCds1, PP1425
NCBI Gene Id11200; 50883;
Description of TargetIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
Uniprot IDO96017, Q9Z265
Molecular Weight60 kDa
  1. What is the species homology for "CHEK2 Antibody (OASG01554)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "CHEK2 Antibody (OASG01554)"?

    This item is available "Domestic: within 2-3 weeks delivery | International: 2-3 weeks".

  3. What buffer format is "CHEK2 Antibody (OASG01554)" provided in?

    This item is provided in "Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CHEK2 Antibody (OASG01554)"?

    This target may also be called "CDS1, CHK2, LFS2, RAD53, hCds1, HuCds1, PP1425" in publications.

  5. What is the shipping cost for "CHEK2 Antibody (OASG01554)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CHEK2 Antibody (OASG01554)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CHEK2 Antibody (OASG01554)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "60 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CHEK2 Antibody (OASG01554)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CHEK2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CHEK2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CHEK2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CHEK2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CHEK2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CHEK2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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