CGB Antibody (OAAD00220)

Catalog No: OAAD00220

Size:100 ug

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: HCG-8
• Isotype: IgG1
• Host: Mouse
• Application: IHC
• Reconstitution and Storage: At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
• Immunogen: Purified human Chorionic Gonadotropin.
• Purification: Purified by Protein A Affinity chromatography.
• Specificity: Human.
  No cross reactivity with other Proteins (hLH, hTSH, or hFSH).
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
• Application Info: Immunohistochemistry(P) At 2ug/ml to detect betaHCG in formalin fixed and paraffin embedded tissues.
  Other applications have not been tested.
  Optimal dilutions should be determined by end user.
• Storage Buffer: Neutral PBS or distilled water. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
• Reference: 1. Bo, M.; Boime, I. : Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. J. Biol. Chem. 267: 3179-3184, 1992.) 2. Policastro, P.; Ovitt, C. E.; Hoshina, M.; Fukuoka, H.; Boothby, M. R.; Biome, I. : The beta-subunit of human chorionic gonadotropin is encoded by multiple genes. J. Biol. Chem. 258: 11492-11499, 1983.
  3. Zygmunt, M.; Herr, F.; Keller-Schoenwetter, S.; Kunzi-Rapp, K.; Munstedt, K.; Rao, C. V.; Lang, U.; Preissner, K. T. : Characterization of human chorionic gonadotropin as a novel angiogenic factor. J.
  Clin. Endocr. Metab. 87: 5290-5296, 2002.

Target Info

• Gene Symbol: CGB
• Gene Full Name: Choriogonadotropin subunit beta
• Alias Symbols: CGB, LHB, CGB5, CGB7, CGB8, hCGB
• NCBI Gene Id: 1082; 93659; 94027; 94115;
• Protein Name: Choriogonadotropin subunit beta
• Description of Target: beta-HCG (beta-Human Chorionic Gonadotropin), also termed as Chorionic Gonadotropin, Beta Chain (CGB).
  It is encoded by a multigene cluster composed of six homologous sequences. And in the family of beta-containing glycoprotein hormones, beta-HCG is unique in that it contains an extension of 29 amino acids at its COOH end. beta-HCG is mapped to 19q13.32 and expressed in trophoblast and various malignant tumors promotes cellular motility in vivo. beta-HCG has a novel function in uterine adaptation to early pregnancy as well as in tumor development and underline the importance of HCG as an as yet unrecognized angiogenic factor.
• Uniprot ID: P0DN86
• Protein Accession #: NP_000728.1; NP_149032.1; NP_149133.1; NP_149439.1
• Nucleotide Accession #: NM_000737.3; NM_033043.1; NM_033142.1; NM_033183.2