CFLAR Antibody - N-terminal region : Biotin (AVARP00022_T100-Biotin)

Catalog No: AVARP00022_T100-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CFLAR
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 86%; Horse: 93%; Human: 100%; Mouse: 80%; Rat: 80%
• Peptide Sequence: Synthetic peptide located within the following region: HQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CFLAR (AVARP00022_T100-Biotin) antibody is Catalog # AAP30495 (Previous Catalog # AAPP01131)
• Sample Type Confirmation:

  CFLAR is strongly supported by BioGPS gene expression data to be expressed in HepG2

• Reference: Kondo,G., et al., (2005) Oncol Rep. 14(5), 1215-22

Target Info

• Gene Symbol: CFLAR
• Gene Full Name: CASP8 and FADD-like apoptosis regulator
• Alias Symbols: CASH, FLIP, MRIT, CLARP, FLAME, cFLIP, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1
• NCBI Gene Id: 8837
• Protein Name: CASP8 and FADD-like apoptosis regulator
• Description of Target: CFLAR might contribute to the carcinogenesis and aggressiveness of endometrial carcinoma and might be a useful prognostic factor in the tumor. CFLAR is specially overexpressed in colon cancers and it might contribute to carcinogenesis of normal colonic mucosa.
• Uniprot ID: O15519
• Protein Accession #: NP_003870
• Nucleotide Accession #: NM_003879
• Protein Size (# AA): 480
• Molecular Weight: 55kDa
• Protein Interactions: FADD; TRAF1; GSN; SPATS1; TNFSF10; RIPK1; RAF1; SMAD3; CASP8; HSP90AA1; STUB1; TNFRSF10A; TNFRSF10B; UBC; FASLG; ITCH; DAXX; CBLB; ATG3; XRCC6; Mib1; TP53; DEDD2; DEDD; RIPK2; IKBKB; MAP2K7; TRAF2; CASP10; CASP7; CASP6; MAP2K4; PSEN2; CASP2; CASP3; BCL2L1