CENPF Recombinant Protein (OPCD02140)

Catalog No: OPCD02140

CENPF Recombinant Protein (OPCD02140) using SDS-PAGE

CENPF Recombinant Protein (OPCD02140) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gln436-Lys637
  Subcellular Location: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoskeleton, spindle.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CENPF
• Gene Full Name: centromere protein F
• Alias Symbols: AH antigen;cell-cycle-dependent 350K nuclear protein;CENF;CENP-F kinetochore protein;centromere protein F;centromere protein F, 350/400kDa;CILD31;hcp-1;kinetochore protein CENPF;mitosin;PRO1779;STROMS.
• NCBI Gene Id: 1063
• Protein Name: Centromere protein F
• Description of Target: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
• Uniprot ID: P49454
• Protein Accession #: NP_057427.3
• Nucleotide Accession #: NM_016343.3
• Protein Size (# AA): Gln436~Lys637
• Molecular Weight: 28kDa