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CEBPA antibody - middle region (ARP57937_P050)

100 ul
$289.00
In Stock

Conjugation Options

ARP57937_P050-FITC Conjugated

ARP57937_P050-HRP Conjugated

ARP57937_P050-Biotin Conjugated

Gene Symbol:
CEBPA
NCBI Gene Id:
1050
Official Gene Full Name:
CCAAT/enhancer binding protein (C/EBP), alpha
Protein Name:
CCAAT/enhancer-binding protein alpha
Swissprot Id:
P49715
Protein Accession #:
NP_004355
Nucleotide Accession #:
NM_004364
Alias Symbols:
C/EBP-alpha, CEBP
Replacement Item:
This antibody may replace item sc-126522 from Santa Cruz Biotechnology.
Description of Target:
CEBPA is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, CEBPA can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2385 U34070.1 592-2976
Protein Size (# AA):
358
Molecular Weight:
37kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CEBPA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CEBPA.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human CEBPA
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 79%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 79%; Zebrafish: 93%
Complete computational species homology data:
Anti-CEBPA (ARP57937_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDT
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
CEBPB; ZBTB16; RARA; HDAC1; BHLHE41; UBC; CEBPE; BATF2; BATF3; YY1AP1; ATF5; BATF; FOSL1; FOS; DBP; CEBPG; CEBPA; ATF4; ATF3; UBE3A; SKP2; RASGRF1; C1QBP; CDKN1A; SRA1; CDK4; PIAS1; Fbxw7; GRIN3A; RAB34; NAA16; POLR1E; MRTO4; AK5; MACF1; KAT5; AKAP9; SMC1
Blocking Peptide:
For anti-CEBPA (ARP57937_P050) antibody is Catalog # AAP57937 (Previous Catalog # AAPP32348)
Datasheets/Manuals:
Printable datasheet for anti-CEBPA (ARP57937_P050) antibody
Additional Information:
IHC Information: Prostate
IHC Information: Colon
Target Reference:
Singh,S.M., (2008) Biochem. Biophys. Res. Commun. 369 (2), 692-694
Publications:

Borger, P. et al. Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients. J. Allergy Clin. Immunol. 123, 639-45 (2009). WB, IHC, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 19121862

Miglino, N., Roth, M., Tamm, M. & Borger, P. House dust mite extract downregulates C/EBP-alpha in asthmatic bronchial smooth muscle cells. Eur. Respir. J. 38, 50-8 (2011). WB, IHC, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish 21109558

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