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CDS1 antibody - middle region (ARP45073_P050)

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100 ul
$319.00
In Stock
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Conjugation Options

ARP45073_P050-FITC Conjugated

ARP45073_P050-HRP Conjugated

ARP45073_P050-Biotin Conjugated

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Gene Symbol:
CDS1
NCBI Gene Id:
1040
Official Gene Full Name:
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Protein Name:
Phosphatidate cytidylyltransferase 1
Swissprot Id:
Q92903
Protein Accession #:
NP_001254
Nucleotide Accession #:
NM_001263
Alias Symbols:
CDS
Description of Target:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. CDS1 is an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis.Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.
Protein Size (# AA):
461
Molecular Weight:
53kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CDS1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CDS1.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human CDS1
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Complete computational species homology data:
Anti-CDS1 (ARP45073_P050)
Peptide Sequence:
Synthetic peptide located within the following region: VVFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQTYSLPPF
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; CDC25C;
Blocking Peptide:
For anti-CDS1 (ARP45073_P050) antibody is Catalog # AAP45073 (Previous Catalog # AAPP12361)
Datasheets/Manuals:
Printable datasheet for anti-CDS1 (ARP45073_P050) antibody
Sample Type Confirmation:

CDS1 is supported by BioGPS gene expression data to be expressed in HEK293T

Target Reference:
Volta,M., (1999) Genomics 55 (1), 68-77
Publications:

Croston, T. L. et al. Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart. Life Sci. 93, 313-22 (2013). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 23872101

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