CDKN1B Antibody (Phospho-Ser178) (OASG05494)

Catalog No: OASG05494

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human p27 around the phosphorylation site of S178. Location: 120-200aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser178
• Specificity: Phospho-p27 (S178) Polyclonal Antibody detects endogenous levels of p27 protein only when phosphorylated at S178.
• Application Info: IHC 1:100-1:300; ELISA 1:5000;

Target Info

• Gene Symbol: CDKN1B
• Gene Full Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
• Alias Symbols: KIP1, MEN4, CDKN4, MEN1B, P27KIP1
• NCBI Gene Id: 1027; 12576;
• Description of Target: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
• Uniprot ID: P46527, P46414
• Molecular Weight: 27 kDa