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CDKN1A Antibody - C-terminal region (OAAB09762)

  • Catalog#: OAAB09762
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Gene Symbol:
CDKN1A
NCBI Gene Id:
1026
Protein Name:
Cyclin-dependent kinase inhibitor 1
Swissprot Id:
P38936
Protein Accession #:
NP_000380.1
Alias Symbols:
CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, p21
Replacement Item:
This antibody may replace item sc-271532 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
18119 Da
Host:
Rabbit
Clonality:
Polyclonal
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Application:
WB, IHC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CDKN1A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CDKN1A.
Predicted Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Human; Mouse
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB09762
Specificity:
This CDKN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human CDKN1A.
Isotype:
Ig
Intended Use:
CDKN1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB 1:1000
IHC 1:10 - 50
IF 1:10 - 50
Additional Information:
Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex
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Cellular Location: Cytoplasm. Nucleus.
Tissue Location: Expressed in all adult tissues, with 5-fold lower levels observed in the brain

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