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Catalog No: AVARP03050_T100
Price: $0.00
SKU
AVARP03050_T100
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for anti-CDK8 (AVARP03050_T100) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Cow, Dog, Horse, Pig, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human CDK8
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Zebrafish: 100%
Peptide SequenceSynthetic peptide located within the following region: GLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
Concentration1.0 mg/ml
Blocking PeptideFor anti-CDK8 (AVARP03050_T100) antibody is Catalog # AAP30436 (Previous Catalog # AAPP01020)
ReferenceAkoulitchev,S., et al., (2000) Nature 407 (6800), 102-106
Gene SymbolCDK8
Gene Full NameCyclin-dependent kinase 8
Alias SymbolsK35, IDDHBA
NCBI Gene Id1024
Protein NameCyclin-dependent kinase 8
Description of TargetThe protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Uniprot IDP49336
Protein Accession #NP_001251
Nucleotide Accession #NM_001260
Protein Size (# AA)464
Molecular Weight53kDa
Protein InteractionsCCNC; MED18; MED15; MED31; MED4; MED13L; MED16; MED6; MED13; MED12; MED24; MED20; MED7; MED27; MED17; MED23; MED21; MED14; HERC2; MED22; MED1; MED11; MED8; MED30; MED10; MED28; MED29; MED9; HNRNPF; CDK8; ERCC3; CCNH; MED19; TCEA1; MBP; CTD; MED26; POLR2A;
  1. What is the species homology for "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Cow, Dog, Horse, Pig, Rabbit, Zebrafish".

  2. How long will it take to receive "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CDK8 Antibody - C-terminal region (AVARP03050_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    This target may also be called "K35, IDDHBA" in publications.

  5. What is the shipping cost for "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "53kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CDK8 Antibody - C-terminal region (AVARP03050_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CDK8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CDK8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CDK8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CDK8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CDK8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CDK8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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