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Datasheets/Manuals | Printable datasheet for CDK4 Antibody - Biotin Conjugated (OACA01803) (OACA01803) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Biotin |
Application | Enzyme-linked immunosorbent assay |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human Cyclin-dependent kinase 4 protein (2-303AA) |
Purification | Protein G Purified |
Purity | Caprylic Acid Ammonium Sulfate Precipitation purified |
Reference | [1] Hanks S.K.Submitted (FEB-1987) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] [2] Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.'Elkahloun A.G., Krizman D.B., Wang Z., Hofmann T.A., Roe B.A., Meltzer P.S.Genomics 42:295-301(1997) [3] A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.'Wolfel T., Hauer M., Schneider J., Serrano M., Wolfel C., Klehmann-Hieb E., De Plaen E., Hankeln T., Meyer Zum Bueschenfelde K.-H., Beach D.Science 269:1281-1284(1995) |
Storage Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Gene Symbol | CDK4 |
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Gene Full Name | cyclin dependent kinase 4 |
Alias Symbols | cell division protein kinase 4;CMM3;cyclin-dependent kinase 4;PSK-J3. |
NCBI Gene Id | 1019 |
Protein Name | Cyclin-dependent kinase 4 |
Description of Target | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
Uniprot ID | P11802 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "CDK4 Antibody - Biotin Conjugated (OACA01803)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
This target may also be called "cell division protein kinase 4;CMM3;cyclin-dependent kinase 4;PSK-J3." in publications.
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What is the shipping cost for "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "CDK4 Antibody - Biotin Conjugated (OACA01803)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "CDK4"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "CDK4"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "CDK4"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "CDK4"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "CDK4"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "CDK4"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.