CDH1 Antibody (OAAD00190)

Catalog No: OAAD00190

Size:100 ug

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Rabbit, Chicken, Snake
• Product Format: Liquid. In PBS with 0.02% sodium azide.
• Clonality: Monoclonal
• Clone: PC-79
• Isotype: IgG1
• Host: Mouse
• Application: WB, IHC
• Reconstitution and Storage: At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
• Immunogen: Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH.
• Purification: Purified by the goat anti-mouse IgG Affinity chromatography.
• Specificity: No cross reactivity with other proteins.
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
• Application Info: Western blot At 1-2ug/ml with the appropriate system to detect pan-cadherin in cells and tissues.
  Immunohistochemistry(P) At 2-4ug/ml to detect pan-cadherin in formalin fixed and paraffin embedded tissues.
  Other applications have not been tested.
  Optimal dilutions should be determined by end user.
• Reference: 1 Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002.
  2 Chalmers, I. J.; Hofler, H.; Atkinson, M. J. : Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Genomics 57: 160-163, 1999.

Target Info

• Gene Symbol: CDH1
• Gene Full Name: Cadherin-1
• Alias Symbols: UVO, CDHE, ECAD, LCAM, Arc-1, BCDS1, CD324
• NCBI Gene Id: 999
• Protein Name: Cadherin-1
• Description of Target: Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are thought to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma
• Uniprot ID: P12830
• Protein Accession #: NP_004351.1
• Nucleotide Accession #: NM_004360.3