Catalog No: AVARP03040_P050
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AVARP03040_P050
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Datasheets/ManualsPrintable datasheet for anti-CDC25A (AVARP03040_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human CDC25A
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceDog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: MELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
Concentration0.5 mg/ml
Blocking PeptideFor anti-CDC25A (AVARP03040_P050) antibody is Catalog # AAP30148 (Previous Catalog # AAPP00305)
ReferenceRay,D. (2008) Cancer Res. 68 (5), 1251-1253
Gene SymbolCDC25A
Gene Full NameCell division cycle 25 homolog A (S. pombe)
Alias SymbolsCDC25A2
NCBI Gene Id993
Protein NameM-phase inducer phosphatase 1
Description of TargetCDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Uniprot IDP30304
Protein Accession #NP_963861
Nucleotide Accession #NM_201567
Protein Size (# AA)484
Molecular Weight54kDa
Protein InteractionsANAPC11; FZR1; FBXW11; BTRC; CUL1; SKP1; VCP; UBC; NPLOC4; YWHAQ; SCYL1; CAMK1D; POLR1D; FGF21; CHEK2; CCNI; MCM3AP; VAMP8; CUL3; XPO1; SOX5; PEX19; NFYA; NFKBIB; MTAP; SMAD3; LMO2; IL3RA; HLA-C; FTH1; EEF1A1; DMD; CHEK1; APP; TRIB3; CSNK1A1; CDK2; FAM193
  1. What is the species homology for "CDC25A Antibody - middle region (AVARP03040_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "CDC25A Antibody - middle region (AVARP03040_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CDC25A Antibody - middle region (AVARP03040_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CDC25A Antibody - middle region (AVARP03040_P050)"?

    This target may also be called "CDC25A2" in publications.

  5. What is the shipping cost for "CDC25A Antibody - middle region (AVARP03040_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CDC25A Antibody - middle region (AVARP03040_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CDC25A Antibody - middle region (AVARP03040_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "54kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CDC25A Antibody - middle region (AVARP03040_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CDC25A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CDC25A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CDC25A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CDC25A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CDC25A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CDC25A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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