Catalog No: OAEE01081
Size:0.1 mg
Price: $209.00
SKU
OAEE01081
Availability: Domestic: within 1 week delivery | International: 1 week
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CD74 Antibody (OAEE01081)

Datasheets/ManualsPrintable datasheet for anti-CD74 (OAEE01081) antibody
Product Info
Predicted Species ReactivityMouse
ClonalityMonoclonal
CloneM5/114
IsotypeIgG2b
HostRat
ApplicationFC, IP, WB, IHC-P, IHC-F, FN
Reconstitution and StorageStore in the dark at 2-8C. Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
ImmunogenActivated C57BL/6 mouse spleen cells
PurificationPurified by size-exclusion chromatography
Concentration0.5 mg/ml
SpecificityThe rat monoclonal antibody M5/114 reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.
FormulationFITC
Storage BufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
ReferenceClausen BE, Waldburger JM, Schwenk F, Barras E, Mach B, Rajewsky K, Förster I, Reith W: Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity. 1998 Feb;8(2):143-55.
Zang W, Kalache S, Lin M, Schroppel B, Murphy B: MHC Class II-mediated apoptosis by a nonpolymorphic MHC Class II peptide proceeds by activation of protein kinase C. J Am Soc Nephrol. 2005 Dec;16(12):3661-8.
Kuwano Y, Prazma CM, Yazawa N, Watanabe R, Ishiura N, Kumanogoh A, Okochi H, Tamaki K, Fujimoto M, Tedder TF: CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. Int Immunol. 2007 Aug;19(8):977-92.
Beers C, Burich A, Kleijmeer MJ, Griffith JM, Wong P, Rudensky AY: Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. J Immunol. 2005 Feb 1;174(3):1205-12.
Kleijmeer M, Ramm G, Schuurhuis D, Griffith J, Rescigno M, Ricciardi-Castagnoli P, Rudensky AY, Ossendorp F, Melief CJ, Stoorvogel W, Geuze HJ: Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J Cell Biol. 2001 Oct 1;155(1):53-63.
De Souza Leao S, Lang T, Prina E, Hellio R, Antoine JC: Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells. J Cell Sci. 1995 Oct;108 ( Pt 10):3219-31.
Viville S, Neefjes J, Lotteau V, Dierich A, Lemeur M, Ploegh H, Benoist C, Mathis D: Mice lacking the MHC class II-associated invariant chain. Cell. 1993 Feb 26;72(4):635-48.
Bhattacharya A, Dorf ME, Springer TA: A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol. 1981 Dec;127(6):2488-95.
Gene SymbolCD74
Gene Full NameHLA class II histocompatibility antigen gamma chain
Alias SymbolsII, p33, DHLAG, HLADG, Ia-GAMMA
NCBI Gene Id972
Protein NameHLA class II histocompatibility antigen gamma chain
Uniprot IDP04233
Protein Accession #NP_001020329.1; NP_001020330.1; NP_004346.1
Nucleotide Accession #NM_001025158.2; NM_001025159.2; NM_004355.3
  1. What is the species homology for "CD74 Antibody (OAEE01081)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".

  2. How long will it take to receive "CD74 Antibody (OAEE01081)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "CD74 Antibody (OAEE01081)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CD74 Antibody (OAEE01081)"?

    This target may also be called "II, p33, DHLAG, HLADG, Ia-GAMMA" in publications.

  5. What is the shipping cost for "CD74 Antibody (OAEE01081)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CD74 Antibody (OAEE01081)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CD74 Antibody (OAEE01081)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CD74 Antibody (OAEE01081)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CD74"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CD74"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CD74"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CD74"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CD74"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CD74"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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