CD68 Polyclonal Antibody (OABB00472)

Catalog No: OABB00472 (Formerly GWB-BBP395)

Size:100UG

Lane 1: Rat Spleen Tissue Lysate
Lane 2: Rat Lung Tissue Lysate

IHC(P): Rat Liver Tissue

Product Info

• Tested Species Reactivity: Mouse, Rat
• Predicted Species Reactivity: Hamster|Mouse|Rat
• Product Format: Lyophilized. Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Frozen|Western blot
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: WB: 0.1-0.5 ug/mL, Rat and Mouse
  IHC-P: 0.5-1 ug/mL. Rat and Mouse. Antigen retrieval is by heat, where boiling the paraffin sections in 10mM citrate buffer (pH 6.0) for 20 mins is required for the staining of formalin/paraffin sections.
  IHC-F: 0.5-1 ug/mL. Mouse, Rat.
  IF 2 ug/mL, Mouse, Rat.
• Publications:

  A Mitochondrial Specific Antioxidant Reverses Metabolic Dysfunction and Fatty Liver Induced by Maternal Cigarette Smoke in Mice. Nutrients. 11, (2019). 31330878

  Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation. Int J Cancer. 138, 2700-12 (2016). 26773796

  Cellular senescence drives age-dependent hepatic steatosis. Nat Commun. 8, 15691 (2017). 28608850

  c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. Nat Metab. 2, 1350-1367 (2020) 33168981

  FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis. JCI Insight. 5, (2020). 32102985

  Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. J Immunol. (2021). 33441438

  Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. J Immunol. (2021). 31877385

  Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice. Aging Cell. 18, e12882 (2019). 30468013

• Description:
  View product citations for CD68 Polyclonal Antibody (OABB00472) on CiteAb

Target Info

• Gene Symbol: Cd68
• Gene Full Name: CD68 antigen
• Alias Symbols: gp11;gp110;La;Lamp4;ma;macrosialin;Sca;Scard1.
• NCBI Gene Id: 12514
• Protein Name: Macrosialin
• Description of Target: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
• Uniprot ID: P31996
• Molecular Weight: 34818 MW