CD45 Antibody - PE Conjugated (OADB00202)

Catalog No: OADB00202

Size:1 mL

A typical staining pattern with the B-A11 monoclonal antibody of lymphocytes

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Monoclonal
• Clone: B-A11
• Isotype: Mouse IgG1
• Host: Human
• Conjugation: PE: Phycoerythrin
• Application: FC
• Reconstitution and Storage: Reconstitute with 1 mL deionised water
  Use 10 uL to label 106 cells or 100 uL of whole blood. Stable at +2-8C for six months after reconstitution. DO NOT FREEZE
• Purification: Ion exchange chromatography
• Concentration: 100 tests/1mL
• Preservative: Sodium Azide
• Specificity: Recognises the Leucocyte Common Antigen (LCA) with different isoforms of 180-190-205-220 kDa
• Formulation: Phosphate-buffered saline with 1% BSA and 0.1% sodium azide
• Storage Buffer: Phosphate-buffered saline with 1% BSA and 0.1% sodium azide
• Reference: Lee, H. S. et al., Stem Cells,2003; 21(2): 190-9.

Target Info

• Gene Symbol: CD45
• Gene Full Name: protein tyrosine phosphatase, receptor type C
• Alias Symbols: LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180
• NCBI Gene Id: 5788
• Protein Name: receptor-type tyrosine-protein phosphatase C
• Description of Target: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
• Uniprot ID: P08575
• Protein Accession #: NP_002829.3
• Nucleotide Accession #: NM_002838.4
• Molecular Weight: 147 kDa