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CD44/CD44 Antibody (OATA00643)

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Tested Species Reactivity:
Human, Mouse
Predicted Species Reactivity:
Chimpanzee, Baboon, Cynomolgus, Rhesus, Swine, Feline, Canine, Equine
Product Format:
Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Clonality:
Monoclonal
Clone:
IM7
Isotype:
Rat IgG2b, kappa
Host:
Rat
Application:
FC
:::
Excitation Laser: Red (633-640 nm)
:::
Emmision: 710 nm
Reconstitution and Storage:
2-8C protected from light
Target:
CD44, CD44
NCBI Gene Id:
12505; 960
Official Gene Full Name:
CD44 molecule (Indian blood group)
Protein Name:
CD44 antigen
Swissprot Id:
P16070, P15379
Protein Accession #:
NP_000601.3
Nucleotide Accession #:
NM_000610.3
Alias Symbols:
IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109
Description of Target:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CD44.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CD44.
Datasheets/Manuals:
Printable datasheet for OATA00643
Specificity:
CD44
Application Info:
This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). Please refer to the figure legend for the optimal concentration used to stain the tissue shown. We recommend titrating the antibody under your specific conditions to determine the optimal concentration of antibody needed in your experimental system.
Target Reference:

Chandler HL, Haeussler DJ, Gemensky-Metzler AJ, Wilkie DA, and Lutz EA. 2012. Invest. Ophthalmol. Vis. Sci. 53:1835-1845. (in vitro blocking, canine)

Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry).

Ruffell B, Poon GFT, Lee SSM, Brown KL, Tjew S-L, Cooper J, and Johnson P. 2011. J. Biol. Chem. 286:19179-19190. (Immunoprecipitation)

Miyake Y, Matsumoto H, Yokoo M, Miyazawa K et al. 2006. Biol. Reprod. 74: 501-510. (Immunohistochemistry - frozen tissue, swine)

Veir JK, Lappin MR, and Dow SW. 2006. Journal of Feline Medicine and Surgery. 8:400-411. (Flow cytometry - feline)

Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, and Frank MH. 2005. Cancer Res. 65:4320-4333. (Immunohistochemistry - frozen tissue)

Fischer A, Schumacher N, Maier M, Sendtner M, and Gessler M. 2004. Genes & Dev. 18:901-911. (Immunohistochemistry - paraffin embedded tissue)

Xu H, Manivannan A, Liversidge J, Sharp PF, Forrester JV, and Crane IJ. 2002. J. Leukoc. Biol. 72:1133-1141. (in vivo functional assays, induction of apoptosis)

Si-Tahar M, Sitaraman S, Shibahara T, and Madara JL. 2001. Am. J. Physiol. Cell Physiol. 280:C423-C432. (in vitro functional assays, Western Blot

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