CD44 Antibody (OAAV00367)

Catalog No: OAAV00367

Size:0.2mg

Product Info

• Tested Species Reactivity: Human, Mouse, Rat, Goat, Primate, Rabbit, Sheep, Bovine
• Product Format: PBS with 0.02% Proclin 300.
• Clonality: Monoclonal
• Clone: Hermes-1
• Isotype: IgG, kappa
• Host: Rabbit
• Application: BL, ELISA, FC, ICC, IF, IHC, IP, NT, WB
• Reconstitution and Storage: Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
• Immunogen: This antibody was produced by immunizing a Fischer rat with human tonsil lymphocytes (10^7cells intraperitoneally in Freund's complete adjuvant). A boost was given 2 weeks later (intravascularly in saline).
• Purification: Protein A affinity purified
• Specificity: This antibody is specific for CD44 (gp90 epitope cluster I), which is selectively expressed on normal or transformed lymphoid cells that are able to recognize and bind to high endothelial venules (specialized vessels that mediate lymphocyte exit from the blood into lymphoid organs). Although this antibody was raised against human CD44, it cross-reacts with murine, rat, rabbit, primate, sheep, bovine and goat CD44.
• Description: This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Target Info

• Gene Symbol: CD44
• Gene Full Name: CD44 molecule (Indian blood group)
• Alias Symbols: IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III
• NCBI Gene Id: 960
• Protein Name: CD44 antigen
• Description of Target: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
• Uniprot ID: P16070
• Protein Accession #: NP_000601.3
• Nucleotide Accession #: NM_000610.3