CD4 Antibody (OAPB01358)

Catalog No: OAPB01358

Size:100UG

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. CD4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Monoclonal
• Host: CD4 monoclonal antibody was raised in mouse.
  Please use anti-mouse secondary antibodies.
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: CD4 monoclonal antibody can be stored at 4C, stable for one year.
• Immunogen: Mouse monoclonal CD4 antibody was raised against a 193 amino acid recombinant protein from near the amino terminus of human CD4.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Application Info: CD4 antibody can be used for detection of CD4 by Western blot at 0.5 – 1 ug/mL. (Optimal dilution should be determined by user)
• Reference: Bowers K, Pitcher C, and Marsh M. CD4 : a co-receptor in the immune response and HIV infection. Int. J. Biochem. Cell Biol. 1997; 29 :871-5.;Arthos J, Deen KC, Chaikin MA, et al. Identification of the residues in human CD4 critical for the binding of HIV. Cell 1989; 57:469-81. ;

Target Info

• Gene Symbol: CD4
• Gene Full Name: CD4 molecule
• Alias Symbols: CD4 antigen (p55);CD4 receptor;CD4mut;IMD79;OKT4D;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4.
• NCBI Gene Id: 920
• Protein Name: T-cell surface glycoprotein CD4|T-cell surface glycoprotein CD4 isoform 1 precursor [Homo sapiens]
• Description of Target: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
• Uniprot ID: P01730
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_000607
• Molecular Weight: Predicted: 51kD Observed: 51-57 kD (Post-modyfication: 2-4 N-linked glycosylations)