Catalog No: OPCA04417
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OPCA04417
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CD3G Recombinant Protein (Crab-eating macaque) (OPCA04417)

Product Info
Predicted Species ReactivityCynomolgus Monkey|Macaca fascicularis
Product FormatLiquid or Lyophilized powder
Additional InformationSpecies Specificity Detail: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Reconstitution and Storage-20°C or -80°C
FormulationTris-base, 50% glycerol
PurityGreater than 90% as determined by SDS-PAGE.
Peptide SequenceQSFEENRKLNVYNQEDGSVLLTCHVKNTNITWFKEGKMIDILTAHKNKWNLGSNTKDPRGVYQCKGSKDKSKTLQVYYRMCQNCIELNAAT
Protein SequenceQSFEENRKLNVYNQEDGSVLLTCHVKNTNITWFKEGKMIDILTAHKNKWNLGSNTKDPRGVYQCKGSKDKSKTLQVYYRMCQNCIELNAAT
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
SourceYeast
Protein Range23-113 aa
TagN-terminal 6xHis-tagged
ReferenceCD3 polymorphism in cynomolgus monkeys (Macaca fascicularis).Uda A., Tanabayashi K., Mukai R., Yachi M., Nam K., Yamada A.J. Med. Primatol. 30:141-147(2001) .
Gene SymbolCD3G
Gene Full NameCD3g molecule
Alias SymbolsCD3 gamma;CD3g molecule, epsilon (CD3-TCR complex);CD3g molecule, gamma (CD3-TCR complex);T-cell receptor T3 gamma chain;T-cell surface glycoprotein CD3 gamma chain.
NCBI Gene Id102134381
Protein NameT-cell surface glycoprotein CD3 gamma chain
Description of TargetPart of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Uniprot IDQ95LI7
Protein Size (# AA)Recombinant
Molecular Weight12.5 kDa
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