CD38 Antibody (OATA00607)

Catalog No: OATA00607

Human peripheral blood lymphocytes were stained with 5 uL (0.5 ug) violetFluor 450 Anti-Human CD38 (OATA00607) (solid line) or 0.5 ug violetFluor 450 Mouse IgG1 isotype control (dashed line).

Human peripheral blood lymphocytes were stained with the recommended volume of violetFluor 450 Anti-Human CD38 (HIT2) manufactured by Aviva Systems Biology (left panel) or Horizon V450 Anti-Human CD38 (HIT2) manufactured by BD Biosciences (right panel).

Product Info

• Tested Species Reactivity: Human
• Product Format: Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
• Clonality: Monoclonal
• Clone: HIT2
• Isotype: Mouse IgG1, kappa
• Host: Mouse
• Application: FC
  Excitation Laser: Violet (405 nm)
  Emmision: 450 nm
• Reconstitution and Storage: 2-8C protected from light
• Specificity: CD38
• Application Info: This antibody preparation has been pre-titrated and quality-tested for flow cytometry using an appropriate cell type. The antibody has been diluted for use at 5 uL per test, defined as the amount of antibody that will stain a cell sample in a final volume of approximately 100 uL. The number of cells within a sample should be determined empirically, but typically ranges between 1x10e5 to 1x10e8 cells.violetFluor 450 dye is excited by the violet (405 nm) laser and has a peak emission of 450 nm. The most common band pass filters for this dye are 440/40 or 450/50. violetFluor 450 can be used as an alternative for Pacific Blue, BD Horizon V450 or eFluor 450.
• Reference:

  Dianzani U, and Malavasi F. 1995. Crit. Rev. Immunol. 15(2):167-200.

  Mehta K, Shahid U, and Malavasi F. Oct. 1996. FASEB J. 10(12):1408-1417.

  Ferrero E, and Malavas F. Feb. 1999. J. Jeukoc. Biol. 65(2):151-161.

  Matrai Z. Feb. 2005. Hematology. 10(1):39-46.

Target Info

• Gene Symbol: CD38
• Gene Full Name: CD38 molecule
• Alias Symbols: ADPRC1, ADPRC 1
• NCBI Gene Id: 952
• Protein Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• Description of Target: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
• Uniprot ID: P28907
• Protein Accession #: NP_001766.2
• Nucleotide Accession #: NM_001775.3