Catalog No: OAEE00837
Size:100T
Price: $299.00
SKU
OAEE00837
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for CD36 Antibody (OAEE00837) (OAEE00837)
Product Info
Predicted Species ReactivityHuman
Product FormatStabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
ClonalityMonoclonal
CloneTR9
IsotypeIgG1
HostMouse
ConjugationR-PE
ApplicationFlow cytometry
Reconstitution and Storage2°C to 8°C
ImmunogenPlatelets
PurificationPurified by size-exclusion chromatography
Concentration20 ul / test
SpecificityThe antibody TR9 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5.
Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes to target cells).
FormulationPE
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
ReferenceWon WJ, Bachmann MF, Kearney JF: CD36 Is Differentially Expressed on B Cell Subsets during Development and in Responses to Antigen. J Immunol. 2008 Jan 1;180(1):230-7.
van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ: Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4. Biochim Biophys Acta. 2007 Dec 15
Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Akhtar Khan N, Montmayeur JP, Besnard P: The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 2007 Dec 27
Gene SymbolCD36
Gene Full NameCD36 molecule
Alias SymbolsBDPLT10;CD36 antigen (collagen type I receptor, thrombospondin receptor);CD36 molecule (thrombospondin receptor);CHDS7;cluster determinant 36;FAT;fatty acid translocase;glycoprotein IIIb;GP3B;GP4;GPIIIB;GPIV;leukocyte differentiation antigen CD36;PAS IV;PAS-4;PAS-4 protein;PASIV;Platelet collagen receptor;platelet glycoprotein 4;platelet glycoprotein IV;SCARB3;scavenger receptor class B, member 3;Thrombospondin receptor.
NCBI Gene Id948
Protein NamePlatelet glycoprotein 4
Description of TargetMultifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).
Uniprot IDP16671
Protein Accession #NP_000063.2; NP_001001547.1; NP_001001548.1; NP_001120915.1; NP_001120916.1; NP_001276837.1
Nucleotide Accession #NM_000072.3; NM_001001547.2; NM_001001548.2; NM_001127443.1; NM_001127444.1; NM_001289908.1
  1. What is the species homology for "CD36 Antibody (OAEE00837)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "CD36 Antibody (OAEE00837)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "CD36 Antibody (OAEE00837)" provided in?

    This item is provided in "Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CD36 Antibody (OAEE00837)"?

    This target may also be called "BDPLT10;CD36 antigen (collagen type I receptor, thrombospondin receptor);CD36 molecule (thrombospondin receptor);CHDS7;cluster determinant 36;FAT;fatty acid translocase;glycoprotein IIIb;GP3B;GP4;GPIIIB;GPIV;leukocyte differentiation antigen CD36;PAS IV;PAS-4;PAS-4 protein;PASIV;Platelet collagen receptor;platelet glycoprotein 4;platelet glycoprotein IV;SCARB3;scavenger receptor class B, member 3;Thrombospondin receptor." in publications.

  5. What is the shipping cost for "CD36 Antibody (OAEE00837)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CD36 Antibody (OAEE00837)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CD36 Antibody (OAEE00837)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CD36 Antibody (OAEE00837)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CD36"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CD36"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CD36"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CD36"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CD36"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CD36"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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