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CD27 Antibody (OAAB20992)

  • Catalog#: OAAB20992
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
Rabbit IgG
Host:
Rabbit
Application:
WB
Additional Information:
Function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Reconstitution and Storage:
Store at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
CD27
Official Gene Full Name:
CD27 molecule
NCBI Gene Id:
939
Swissprot Id:
P26842
Protein Accession #:
NP_001233.1
Nucleotide Accession #:
NM_001242.4
Alias Symbols:
T14, S152, Tp55, TNFRSF7, S152. LPFS2
Replacement Item:
This antibody may replace item sc-1740 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Molecular Weight:
29 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CD27.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CD27.
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Concentration:
1 mg/mL
Datasheets/Manuals:
Printable datasheet for anti-CD27 (OAAB20992) antibody
Preservative:
0.02% Sodium Azide and 50% glycerol
Formulation:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target Reference:
Camerini D.,et al.J. Immunol. 147:3165-3169(1991).
Loenen W.A.,et al.J. Immunol. 149:3937-3943(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).

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