CD247/CD3D/CD3E/CD3G Antibody (OATA00523)

Catalog No: OATA00523

Size:100 ug

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Chimpanzee
• Product Format: Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2
• Clonality: Monoclonal
• Clone: Hit3a
• Isotype: Mouse IgG2a, kappa
• Host: Mouse
• Conjugation: Unconjugated
• Application: FC, IHC-F, IP
• Reconstitution and Storage: 2-8C
• Specificity: CD3
• Application Info: This purified format is guaranteed to be >90% pure as determined by SDS-PAGE analysis. Aviva tests all of our antibodies by flow cytometry. Citations may be provided as a resource for additional applications that have not been validated by Aviva - please consult Materials and Methods sections for additional details about the use of any product in these publications.
• Reference:

  Lesourne R, Zvezdova E, Song K-D, El-Khoury D, Uehara S, Barr VA, Samelson LE and Love PE. 2012. J. Immunol. 189: 1154-1161. (in vitro activation)

  Knyazhitsky M, Moas E, Shaginov E, Luria A, and Braiman A. 2012. J. Biol. Chem. 287: 19725-19735. (in vitro activation)

  Ge Shuwang, Hertel B, Emden SH, Beneke J, Menne J, Haller H, and von Vietinghoff S. 2012. Nephrol. Dial. Transplant. 27: 2768-2772. (Immunofluorescence microscopy)

  Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, and Varki A. 2010. J. Immunol. 184: 4185-4195. (Flow cytometry - Chimpanzee)

  Westermann J, Bode U, Sahle A, Speck U, Karin N, Bell EB, Kalies K, and Gebert A. 2005. J. Immunol. 174: 2517-2524. (Immunohistochemistry - frozen tissue)

  Mukouyama H, Janzen NK, Hernandez JM, Lam JS, Caliliw R, Wang AY, Figlin RA, Belldegrun AS, and Zeng G. 2004. Clin. Cancer Res. 10: 1421-1429. (in vitro blocking)

Target Info

• Gene Symbol: CD247, CD3D, CD3E, CD3G
• Gene Full Name: CD247 molecule
• Alias Symbols: T3D, IMD19, CD3-DELTA
• NCBI Gene Id: 915; 916; 917; 919
• Protein Name: T-cell surface glycoprotein CD3 zeta chain
• Description of Target: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Uniprot ID: P20963, A8MVP6, P07766, P09693
• Protein Accession #: NP_000725.1
• Nucleotide Accession #: NM_000734.3