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Catalog No: OPCD01981
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OPCD01981
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Datasheets/ManualsPrintable datasheet for CD14 Recombinant Protein (OPCD01981)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ser18-Val372
::Subcellular Location: Cell membrane; Lipid-anchor, GPI-anch
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolCd14
Gene Full NameCD14 molecule
Alias SymbolsCD14 antigen;monocyte differentiation antigen CD14;myeloid cell-specific leucine-rich glycoprotein.
NCBI Gene Id60350
Protein NameMonocyte differentiation antigen CD14
Description of TargetCoreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
Uniprot IDQ63691
Protein Accession #NP_068512.1
Nucleotide Accession #NM_021744.1
Protein Size (# AA)Ser18~Val372
Molecular Weight70kDa
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