CCR8 Antibody - middle region (AVARP09059_T100)

Catalog No: AVARP09059_T100

WB Suggested Anti-CCR8 Antibody Titration: 2.5ug/ml
Positive Control: K562 cell lysateCCR8 is supported by BioGPS gene expression data to be expressed in K562

Host: Rabbit
Target Name: CCR8
Sample Tissue: Human 786-0 Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Cow, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCR8
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Human: 100%; Rabbit: 81%
• Peptide Sequence: Synthetic peptide located within the following region: MATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFT
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-CCR8 (AVARP09059_T100) antibody is Catalog # AAP30774 (Previous Catalog # AAPP01437)
• Sample Type Confirmation:

  CCR8 is supported by BioGPS gene expression data to be expressed in K562

Target Info

• Reference: Haque,N.S., et al., (2004) Blood 103 (4), 1296-1304
• Gene Symbol: CCR8
• Gene Full Name: Chemokine (C-C motif) receptor 8
• Alias Symbols: CY6, TER1, CCR-8, CKRL1, CDw198, CMKBR8, GPRCY6, CMKBRL2, CC-CKR-8
• NCBI Gene Id: 1237
• Protein Name: C-C chemokine receptor type 8
• Description of Target: CCR8 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. Its gene is located at the chemokine receptor gene cluster region.
• Uniprot ID: P51685
• Protein Accession #: NP_005192
• Nucleotide Accession #: NM_005201
• Protein Size (# AA): 355
• Molecular Weight: 41kDa
• Protein Interactions: TPST2; TPST1; CCR8; CCL17; CCL16; CCL4; CCL1;