CCND1 Recombinant Protein (OPCD01971)

Catalog No: OPCD01971

CCND1 Recombinant Protein (OPCD01971) using SDS-PAGE

CCND1 Recombinant Protein (OPCD01971) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Ile295
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: CCND1
• Gene Full Name: cyclin D1
• Alias Symbols: B-cell CLL/lymphoma 1;B-cell lymphoma 1 protein;BCL1;BCL-1 oncogene;D11S287E;G1/S-specific cyclin-D1;PRAD1;PRAD1 oncogene;U21B31.
• NCBI Gene Id: 595
• Protein Name: G1/S-specific cyclin-D1
• Description of Target: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
• Uniprot ID: P24385
• Protein Accession #: NP_444284.1
• Nucleotide Accession #: NM_053056.2
• Protein Size (# AA): Met1~Ile295
• Molecular Weight: 63kDa