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Catalog No: OAEE00365
Size:100UG
Price: $259.00
SKU
OAEE00365
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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CCND1 Antibody (OAEE00365)

Datasheets/ManualsPrintable datasheet for CCND1 Antibody (OAEE00365) (OAEE00365)
Product Info
Predicted Species ReactivityHuman|Rat
Product FormatStabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
ClonalityMonoclonal
CloneCD1.1
IsotypeIgG1
HostMouse
ApplicationEnzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Reconstitution and Storage2°C to 8°C
ImmunogenPurified cyclin D1 protein
PurificationPurified
Concentration1 mg/ml
SpecificityThe antibody CD1.1 recognizes cyclin D1, an ubiquitously expressed 33 kDa protein that migrates as a 36 kDa band under reducing SDS-PAGE conditions.
FormulationPurified
Purity> 95% (by SDS-PAGE)
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
ReferenceDiehl JA, Zindy F, Sherr CJ: Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 1997 Apr 15;11(8):957-72.
Mukherji A, Janbandhu VC, Kumar V: GSK-3beta-dependent destabilization of cyclin D1 mediates replicational stress-induced arrest of cell cycle. FEBS Lett. 2008 Mar 6
Yang W, Zhang Y, Li Y, Wu Z, Zhu D: Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1. J Biol Chem. 2007 Feb 9;282(6):3799-808.
Diehl JA, Cheng M, Roussel MF, Sherr CJ: Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998 Nov 15;12(22):3499-511.
Gene SymbolCCND1
Gene Full Namecyclin D1
Alias SymbolsB-cell CLL/lymphoma 1;B-cell lymphoma 1 protein;BCL1;BCL-1 oncogene;D11S287E;G1/S-specific cyclin-D1;PRAD1;PRAD1 oncogene;U21B31.
NCBI Gene Id595
Protein NameG1/S-specific cyclin-D1
Description of TargetRegulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Uniprot IDP24385
Protein Accession #NP_444284.1
Nucleotide Accession #NM_053056.2
  1. What is the species homology for "CCND1 Antibody (OAEE00365)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Rat".

  2. How long will it take to receive "CCND1 Antibody (OAEE00365)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "CCND1 Antibody (OAEE00365)" provided in?

    This item is provided in "Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CCND1 Antibody (OAEE00365)"?

    This target may also be called "B-cell CLL/lymphoma 1;B-cell lymphoma 1 protein;BCL1;BCL-1 oncogene;D11S287E;G1/S-specific cyclin-D1;PRAD1;PRAD1 oncogene;U21B31." in publications.

  5. What is the shipping cost for "CCND1 Antibody (OAEE00365)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CCND1 Antibody (OAEE00365)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CCND1 Antibody (OAEE00365)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CCND1 Antibody (OAEE00365)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CCND1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CCND1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CCND1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CCND1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CCND1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CCND1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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