CCND1 Antibody - middle region (AVARP03037_P050)

Catalog No: AVARP03037_P050

WB Suggested Anti-CCND1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCND1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 90%; Dog: 90%; Guinea Pig: 100%; Horse: 90%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 81%
• Peptide Sequence: Synthetic peptide located within the following region: ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CCND1 (AVARP03037_P050) antibody is Catalog # AAP30439 (Previous Catalog # AAPP01023)

Target Info

• Reference: Kibel,A.S., (2008) Prostate 68 (11), 1179-1186
• Gene Symbol: CCND1
• Gene Full Name: Cyclin D1
• Alias Symbols: BCL1, PRAD1, U21B31, D11S287E
• NCBI Gene Id: 595
• Protein Name: G1/S-specific cyclin-D1
• Description of Target: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P24385
• Protein Accession #: NP_444284
• Nucleotide Accession #: NM_053056
• Protein Size (# AA): 295
• Molecular Weight: 34kDa
• Protein Interactions: CDKN1B; CDKN1A; CDK4; RELA; FBXO31; UBC; FBXO4; CAMK1; TP73; RB1; CDK2; HSPA8; POLR1B; MCM10; ORC4; LPL; BRINP1; CDK6; RABEP1; CARD11; CUL1; RBL2; UBTF; CCND1; ATF2; CDKN2A; FBXW8; BTRC; PPP1CC; PPP1CB; PSMA6; ITLN1; MCM7; MCM6; MCM3; MCM2; ELAVL1; PCNA;