Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP30163_P050
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Conjugation Options

ARP30163_P050-FITC Conjugated

ARP30163_P050-HRP Conjugated

ARP30163_P050-Biotin Conjugated

CCND1 Antibody - middle region (ARP30163_P050)

Rating:
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Catalog#: ARP30163_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species ReactivityHuman
Predicted Species ReactivityCow, Dog, Horse, Human, Pig, Rabbit, Rat, Yeast, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-166288 from Santa Cruz Biotechnology.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human CCND1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 92%; Dog: 92%; Horse: 92%; Human: 100%; Pig: 91%; Rabbit: 83%; Rat: 85%; Yeast: 83%; Zebrafish: 79%
Complete computational species homology dataAnti-CCND1 (ARP30163_P050)
Peptide SequenceSynthetic peptide located within the following region: ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking PeptideFor anti-CCND1 (ARP30163_P050) antibody is Catalog # AAP30163 (Previous Catalog # AAPS08607)
Datasheets/ManualsPrintable datasheet for anti-CCND1 (ARP30163_P050) antibody
Target ReferenceKibel,A.S., (2008) Prostate 68 (11), 1179-1186
Gene SymbolCCND1
Official Gene Full NameCyclin D1
Alias SymbolsBCL1, D11S287E, PRAD1, U21B31
NCBI Gene Id595
Protein NameG1/S-specific cyclin-D1
Description of TargetCCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot IdP24385
Protein Accession #NP_444284
Nucleotide Accession #NM_053056
Protein Size (# AA)295
Molecular Weight34kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express CCND1.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express CCND1.
Protein InteractionsCDKN1B; CDKN1A; CDK4; RELA; FBXO31; UBC; FBXO4; CAMK1; TP73; RB1; CDK2; HSPA8; POLR1B; MCM10; ORC4; LPL; BRINP1; CDK6; RABEP1; CARD11; CUL1; RBL2; UBTF; CCND1; ATF2; CDKN2A; FBXW8; BTRC; PPP1CC; PPP1CB; PSMA6; ITLN1; MCM7; MCM6; MCM3; MCM2; ELAVL1; PCNA;
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