Size:100 ul
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Conjugation Options

AVARP07046_P050-FITC Conjugated

AVARP07046_P050-HRP Conjugated

AVARP07046_P050-Biotin Conjugated

CCL2 Antibody - middle region (AVARP07046_P050)

Catalog#: AVARP07046_P050
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Dog, Human
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application IHC, WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-130328, HPA019163
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human CCL2
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Dog: 75%; Human: 100%
Complete computational species homology data Anti-CCL2 (AVARP07046_P050)
Peptide Sequence Synthetic peptide located within the following region: ASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPK
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-CCL2 (AVARP07046_P050) antibody is Catalog # AAP30817 (Previous Catalog # AAPP01481)
Datasheets/Manuals Printable datasheet for anti-CCL2 (AVARP07046_P050) antibody
Target Reference Carulli,M.T., (2008) J. Rheumatol. 35 (5), 839-844
Pottekat, A. et al. (2013). Cell Reports 4, 921-930.
Gene Symbol CCL2
Official Gene Full Name Chemokine (C-C motif) ligand 2
Alias Symbols GDCF-2, GDCF-2 HC11, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
NCBI Gene Id 6347
Protein Name C-C motif chemokine 2
Description of Target CCL2 is a chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. CCL2 augments monocyte anti-tumor activity. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. CCL2 may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id P13500
Protein Accession # NP_002973
Nucleotide Accession # NM_002982
Protein Size (# AA) 99
Molecular Weight 11kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express CCL2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express CCL2.
Protein Interactions Ccr2; CDC45; PCNA; ORC4; ORC2; MCM7; MCM3; MCM2; CDC6; ACKR2; ACKR4; CCR5; CCR1; CCR10; MMP3; CCL2; MMP8; MMP1; VCAN; ACKR1; CCL5; CCR3;
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