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CCL2 Antibody - middle region (AVARP07046_P050)

100 ul
$289.00
In Stock
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Conjugation Options

AVARP07046_P050-FITC Conjugated

AVARP07046_P050-HRP Conjugated

AVARP07046_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Dog, Human
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
IHC, WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
CCL2
Official Gene Full Name:
Chemokine (C-C motif) ligand 2
NCBI Gene Id:
6347
Protein Name:
C-C motif chemokine 2
Swissprot Id:
P13500
Protein Accession #:
NP_002973
Nucleotide Accession #:
NM_002982
Alias Symbols:
GDCF-2, GDCF-2 HC11, HC11, HSMCR30, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF
Replacement Item:
This antibody may replace item sc-130328, HPA019163
Description of Target:
CCL2 is a chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. CCL2 augments monocyte anti-tumor activity. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. CCL2 may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
99
Molecular Weight:
11kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CCL2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CCL2.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human CCL2
Predicted Homology Based on Immunogen Sequence:
Dog: 75%; Human: 100%
Complete computational species homology data:
Anti-CCL2 (AVARP07046_P050)
Peptide Sequence:
Synthetic peptide located within the following region: ASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPK
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
Ccr2; CDC45; PCNA; ORC4; ORC2; MCM7; MCM3; MCM2; CDC6; ACKR2; ACKR4; CCR5; CCR1; CCR10; MMP3; CCL2; MMP8; MMP1; VCAN; ACKR1; CCL5; CCR3;
Blocking Peptide:
For anti-CCL2 (AVARP07046_P050) antibody is Catalog # AAP30817 (Previous Catalog # AAPP01481)
Datasheets/Manuals:
Printable datasheet for anti-CCL2 (AVARP07046_P050) antibody
Target Reference:
Carulli,M.T., (2008) J. Rheumatol. 35 (5), 839-844
Pottekat, A. et al. (2013). Cell Reports 4, 921-930.

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