CCDC88A Antibody (OAAF01637)

Catalog No: OAAF01637 (Formerly GWB-ASC975)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Girdin Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human Girdin.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: Girdin antibody detects endogenous levels of total Girdin protein.
• Dilution: The optimal working dilution should be determined by the end user.
• Intended Use: The product is for research use only, not for use in diagnostic or therapeutic procedures.
• Application Info: IHC 1:50~100
  ELISA 1:1000
  
• Reference: Enomoto A., Dev. Cell 9:389-402(2005).
  Simpson F., Traffic 6:442-458(2005).
  Hillier L.W., Nature 434:724-731(2005).

Target Info

• Gene Symbol: CCDC88A
• Gene Full Name: coiled-coil domain containing 88A
• Alias Symbols: Akt phosphorylation enhancer;AKT-phosphorylation enhancer;APE;Coiled-coil domain-containing protein 88A;g alpha-interacting vesicle-associated protein;Girders of actin filament;girders of actin filaments;girdin;GIV;GRDN;HkRP1;Hook-related protein 1;KIAA1212;PEHO;PEHOL.
• NCBI Gene Id: 55704
• Protein Name: Girdin
• Description of Target: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382).
• Uniprot ID: Q3V6T2
• Protein Accession #: NP_001129069.1
• Molecular Weight: 216 kDa