CCBP2 Antibody (OAAF04863)

Catalog No: OAAF04863 (Formerly GWB-ASF264)

Size:100 ug

Immunofluorescence analysis of A549 cells, using CCBP2 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human CCBP2.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: CCBP2 antibody detects endogenous levels of total CCBP2 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IF: 1:100~1:500; ELISA: 1:20000
• Reference: Bonini J.A., DNA Cell Biol. 16:1249-1256(1997).
  Nibbs R.J.B., J. Biol. Chem. 272:32078-32083(1997).
  Kopatz S.A., Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.

Target Info

• Gene Symbol: ACKR2
• Gene Full Name: atypical chemokine receptor 2
• Alias Symbols: atypical chemokine receptor 2;C-C chemokine receptor D6;CCBP2;CC-chemokine-binding receptor JAB61;CCR10;CCR9;chemokine (C-C motif) receptor 9;chemokine (C-C) receptor 9;chemokine receptor CCR-10;chemokine receptor CCR-9;chemokine receptor D6;chemokine-binding protein 2;chemokine-binding protein D6;CMKBR9;D6;hD6.
• NCBI Gene Id: 1238
• Protein Name: Atypical chemokine receptor 2
• Description of Target: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
• Uniprot ID: O00590
• Protein Accession #: NP_001287.2
• Molecular Weight: 43 kDa