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CBS Antibody (OAGA01010)

100 ul
$409.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
ICC, IF, IHC-FFPE, WB
Additional Information:
Background: The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. [provided by RefSeq]
:::
Positive Controls: 293T
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Cellular Localization: Cytoplasm, Nucleus
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Gene Symbol:
CBS
Official Gene Full Name:
Cystathionine beta-synthase
NCBI Gene Id:
875
Protein Name:
Cystathionine beta-synthase
Swissprot Id:
P35520
Protein Accession #:
NP_000062.1
Alias Symbols:
HIP4 antibody, CBS antibody, serine sulfhydrase antibody, beta-thionase antibody, cystathionine beta-synthase antibody, methylcysteine synthase antibody, cystathionine-beta-synthase antibody
Replacement Item:
This antibody may replace item sc-111129 from Santa Cruz Biotechnology.
Molecular Weight:
61 kDa
Purification:
Purified by antigen-affinity chromatography.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CBS.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CBS.
Immunogen:
Recombinant fragment corresponding to a region within amino acids 39 and 251 of CBS (Uniprot ID#P35520)
Concentration:
0.69 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-CBS antibody - OAGA01010
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000 [suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)], ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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