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Catalog No: OPCD00702
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OPCD00702
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Datasheets/ManualsPrintable datasheet for CBR1 Recombinant Protein (OPCD00702)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Asn66-Asp271
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His Tag
Gene SymbolCbr1
Gene Full Namecarbonyl reductase 1
Alias Symbols15-hydroxyprostaglandin dehydrogenase;15-hydroxyprostaglandin dehydrogenase [NADP(+)];20-beta-hydroxysteroid dehydrogenase;AW261796;C;carbonyl reductase [NADPH] 1;Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1);Cbr;CR;NADPH-dependent carbonyl reductase 1;PG-9-KR;prostaglandin 9-ketoreductase;prostaglandin-E(2) 9-reductase.
NCBI Gene Id12408
Protein NameCarbonyl reductase [NADPH] 1
Description of TargetNADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity).
Uniprot IDP48758
Protein Accession #NP_031646.2
Nucleotide Accession #NM_007620.2
Protein Size (# AA)Asn66~Asp271
Molecular Weight30kDa
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