CBR1 Antibody (OAAB20980)

Catalog No: OAAB20980

Size:100ul

Western blot detection of CBR1 in Hela, A431 and MDA-MB-468 cell lysates using CBR1 mouse mAb (OAAB20980) (1:1,000 diluted). Predicted band size: 30KDa, Observed band size: 30KDa.

Immunocytochemistry stain of Hela using CBR1 mouse mAb (OAAB20980) (1:100).

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Host: Rabbit
• Application: WB, ICC
• Additional Information: Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Formulation: Purified mouse monoclonal in PBS (pH 7.4)containing with 0.2% sodium azide,50% glycerol.
• Application Info: WB: 1:1000
  ICC: 1:100
• Reference: Wermuth B.,et al.J. Biol. Chem. 263:16185-16188(1988).
  Forrest G.L.,et al.Biochim. Biophys. Acta 1048:149-155(1990).
  Forrest G.L.,et al.Mol. Pharmacol. 40:502-507(1991).
  Watanabe K.,et al.Genomics 52:95-100(1998).
  Terada T.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
  

Target Info

• Gene Symbol: CBR1
• Gene Full Name: carbonyl reductase 1
• Alias Symbols: CBR, hCBR1, PG-9-KR, SDR21C1
• NCBI Gene Id: 873
• Description of Target: The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene.
• Uniprot ID: P16152
• Protein Accession #: NP_001273718.1
• Nucleotide Accession #: NM_001286789.1
• Molecular Weight: 30 kDa