CBFB Recombinant Protein (OPCD00687)

Catalog No: OPCD00687

CBFB Recombinant Protein (OPCD00687) using SDS-PAGE

CBFB Recombinant Protein (OPCD00687) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Arg187
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Cbfb
• Gene Full Name: core binding factor beta
• Alias Symbols: AI893578;CBF-beta;core-binding factor subunit beta;PE;PEA2;PEA2-beta;Peb;Pebp;Pebp2;PEBP2b;PEBP2-beta;Pebpb2;polyomavirus enhancer-binding protein 2 beta subunit;SL3/AKV core-binding factor beta subunit;SL3-3 enhancer factor 1 subunit beta.
• NCBI Gene Id: 12400
• Protein Name: Core-binding factor subunit beta
• Description of Target: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917).
• Uniprot ID: Q08024
• Protein Accession #: NP_001154928.1
• Nucleotide Accession #: NM_001161456.1
• Protein Size (# AA): Met1~Arg187
• Molecular Weight: 26kDa