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CBFA2T2 Antibody (OAGA00723)

100 ul
$409.00
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Gene Symbol:
CBFA2T2
Official Gene Full Name:
Protein CBFA2T2
NCBI Gene Id:
9139
Protein Name:
Protein CBFA2T2
Swissprot Id:
O43439
Protein Accession #:
NP_001028171.1
Alias Symbols:
DKFZp313F2116 antibody, EHT antibody, MTGR1 antibody, ZMYND3 antibody, p85 antibody, CBFA2T2 antibody, myeloid translocation gene-related protein 1 antibody, MTG8-like protein antibody, MTG8-related protein 1 antibody, ETO homolog on chromosome 20 antibod
Replacement Item:
This antibody may replace item sc-390114 from Santa Cruz Biotechnology.
Molecular Weight:
67 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by antigen-affinity chromatography.
Application:
ICC, IF, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CBFA2T2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CBFA2T2.
Immunogen:
Recombinant fragment corresponding to a region within amino acids 401 and 604 of CBFA2T2 (Uniprot ID#O43439)
Predicted Species Reactivity:
Human
Product Format:
Liquid
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Concentration:
1 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-CBFA2T2 antibody - OAGA00723
Isotype:
IgG
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Additional Information:
Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq]
:::
Positive Controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
:::
Cellular Localization: Nucleus
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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