CBARA1 Antibody - N-terminal region (OAAB06279)

Catalog No: OAAB06279

Size:400UL

Western blot analysis of CBAA1 Antibody (N-term) in K562 cell lysates (35ug/lane). CBAA1 (arrow) was detected using the purified Pab.

CBARA1 is strongly supported by BioGPS gene expression data to be expressed in K562

Product Info

• Predicted Species Reactivity: Human|Primate
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This CBAA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human CBAA1.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  CBARA1 is strongly supported by BioGPS gene expression data to be expressed in K562

• Application Info: WB: 1:1000

Target Info

• Gene Symbol: CBARA1
• Alias Symbols: ara CALC, atopy-related autoantigen CALC, CALC, calcium uptake protein 1, mitochondrial, calcium-binding atopy-related autoantigen 1, Calcium-binding atopy-related autoantigen 1 homolog, CBARA1, EFHA3, MPXPS.
• NCBI Gene Id: 10367
• Protein Name: Calcium uptake protein 1, mitochondrial|calcium uptake protein 1, mitochondrial isoform 1 [Homo sapiens]|calcium uptake protein 1, mitochondrial isoform 2 [Homo sapiens]|calcium uptake protein 1, mitochondrial isoform 3 [Homo sapiens]
• Description of Target: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).|Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
• Uniprot ID: Q4R518|Q9BPX6
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001182447.1,NP_001182448.1,NP_006068.2
• Molecular Weight: 54351