Catalog No: OPCD01924
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Datasheets/ManualsPrintable datasheet for OPCD01924
Product Info
Predicted Species ReactivityHuman
Product FormatLyophilized PBS (pH 7.4) containing 0.01% SKL and 5% Trehalose
ApplicationSDS-PAGE, WB, ELISA, IP
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Residues: Ser2-Ser104
Subcellular Location: Membrane
Isoelectric Point: 5.7
Reconstitution and StorageReconstitute in 10mM PBS (pH 7.4) to a concentration of 0.1-1.0 mg/ml. Do not vortex. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Avoid repeated freeze/thaw cycles.
Concentration800 ug/mL (prior to lyoph)
Purity> 97%
SourceProkaryotic Expressed Recombinant
TagN-terminal His Tag
Gene SymbolCAV1
Gene Full Namecaveolin 1
Alias SymbolsCGL3, PPH3, BSCL3, LCCNS, VIP21, MSTP085
NCBI Gene Id857
Protein NameCaveolin-1
Description of TargetMay act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation .
Uniprot IDQ03135
Protein Accession #NP_001744.2
Nucleotide Accession #NM_001753.4
Molecular Weight13 kDa
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