CAV1 Recombinant Protein (OPCD01924)

Catalog No: OPCD01924

CAV1 Recombinant Protein (OPCD01924) using SDS-PAGE

CAV1 Recombinant Protein (OPCD01924) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Lyophilized 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser2-Ser104
  Subcellular Location: Membrane
  Isoelectric Point: 5.7
• Reconstitution and Storage: Reconstitute in 20mM Tris, 150mM NaCl (pH 8.0) to a concentration of 0.1-1.0 mg/ml. Do not vortex. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. Avoid repeated freeze/thaw cycles.
• Concentration: 500 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CAV1
• Gene Full Name: caveolin 1
• Alias Symbols: BSCL3;caveolin 1, caveolae protein, 22kDa;caveolin-1;cell growth-inhibiting protein 32;CGL3;LCCNS;MSTP085;PPH3;VIP21.
• NCBI Gene Id: 857
• Protein Name: Caveolin-1
• Description of Target: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).
• Uniprot ID: Q03135
• Protein Accession #: NP_001744.2
• Nucleotide Accession #: NM_001753.4
• Protein Size (# AA): Ser2~Ser104
• Molecular Weight: 13 kDa