- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for CASR Antibody (OAAF00973) |
---|
Predicted Species Reactivity | Human|Mouse|Rat |
---|---|
Product Format | Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Application | Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot |
Reconstitution and Storage | -20°C |
Immunogen | The antiserum was produced against synthesized peptide derived from human Calcium Sensing Receptor. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration | 1 mg/ml |
Specificity | Calcium Sensing Receptor (Ab-888) antibody detects endogenous levels of total Calcium Sensing Receptor protein. |
Dilution | The optimal working dilution should be determined by the end user. |
Application Info | WB: 1:500~1000 IHC: 1:50~100 ELISA: 1:5000 |
Reference | Garrett J.E., J. Biol. Chem. 270:12919-12925(1995). Aida K., Biochem. Biophys. Res. Commun. 214:524-529(1995). Huang Y., J. Biol. Chem. 281:11610-11617(2006) |
Gene Symbol | CASR |
---|---|
Gene Full Name | calcium sensing receptor |
Alias Symbols | CAR;EIG8;extracellular calcium-sensing receptor;FHH;FIH;GPRC2A;hCasR;HHC;HHC1;HYPOC1;NSHPT;parathyroid Ca(2+)-sensing receptor 1;parathyroid cell calcium-sensing receptor 1;PCAR1. |
NCBI Gene Id | 846 |
Protein Name | Extracellular calcium-sensing receptor |
Description of Target | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). |
Uniprot ID | P41180 |
Protein Accession # | NP_000379.2 |
Molecular Weight | 120 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "CASR Antibody (OAAF00973)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".
-
How long will it take to receive "CASR Antibody (OAAF00973)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
-
What buffer format is "CASR Antibody (OAAF00973)" provided in?
This item is provided in "Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "CASR Antibody (OAAF00973)"?
This target may also be called "CAR;EIG8;extracellular calcium-sensing receptor;FHH;FIH;GPRC2A;hCasR;HHC;HHC1;HYPOC1;NSHPT;parathyroid Ca(2+)-sensing receptor 1;parathyroid cell calcium-sensing receptor 1;PCAR1." in publications.
-
What is the shipping cost for "CASR Antibody (OAAF00973)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "CASR Antibody (OAAF00973)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "CASR Antibody (OAAF00973)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "120 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "CASR Antibody (OAAF00973)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "CASR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "CASR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "CASR"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "CASR"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "CASR"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "CASR"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.