CASR Antibody - middle region (OAAB15544)

Catalog No: OAAB15544

Size:400ul

CASR Antibody (Center) (Cat. # OAAB15544) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CASR antibody detected the CASR protein (arrow).

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Cellular Location: Cell membrane; Multi-pass membrane protein.
  Tissue Location: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This CASR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-287 amino acids from the Central region of human CASR.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Bovine, Pig, Rat
• Concentration: 0.5 mg/ml
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: CASR
• Alias Symbols: CAR, FHH, FIH, HHC, EIG8, HHC1, NSHPT, PCAR1, hCasR, GPRC2A, HYPOC1
• NCBI Gene Id: 846
• Protein Name: Extracellular calcium-sensing receptor
• Description of Target: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
• Uniprot ID: P41180
• Protein Accession #: NP_000379.2
• Molecular Weight: 121 kDa