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CASPR Antibody (OASE00218)

  • Catalog#: OASE00218
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100ug
$350.00
Discontinued
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Conjugation Options

OASE00218-FITC Conjugated

OASE00218-HRP Conjugated

OASE00218-Biotin Conjugated

Gene Symbol:
CNTNAP1
NCBI Gene Id:
8506
Official Gene Full Name:
contactin associated protein 1
Swissprot Id:
P78357
Protein Accession #:
NP_003623.1
Replacement Item:
This antibody may replace item sc-41916 from Santa Cruz Biotechnology.
Description of Target:
Scientific Background: Caspr (contactin-associated protein) is a part of the neurexin family. It lies in the paranodal section of the myelin sheath.Its role is for myelin sheath attachment along with contactin in a cis-complex (3). Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction, whereas Caspr serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region. Both interact with protein 4.1B (4).
Host:
Mouse
Clonality:
Monoclonal
Purification:
Protein G Purified
Application:
WB, IHC, IP
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CNTNAP1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CNTNAP1.
Immunogen:
Fusion protein 1308-1381 (cytoplasmic domain) of rat CASPR, accession number
P97846.
Predicted Species Reactivity:
Human, Mouse, Rat
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Concentration:
1mg/mL
Datasheets/Manuals:
Printable datasheet for OASE00218
Clone:
S65-35
Isotype:
IgG1
Application Info:
WB:1ug/mL
IHC/ICC: 0.1-1ug/mL

IF: 1-10ug/mL
Application Data:
Background Info: Detects ~220kDa.
:::
Certificate of Analysis: 1 ug/mL was sufficient for detection of CASPR in 20ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Storage Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Target Reference:
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA.,
2. www.iochannels.org,
3. www.en.wikipedia.org/wiki/Caspr,
4. Horresh I., Bar V., Kissil J.L., and Peles E. (2010) J.Neurosci. 30(7): 2480-2489.

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